Les récepteurs nucléaires CAR et PXR contrôlent l’induction des cytochromes P450 par le phénobarbital
Author:
Publisher
EDP Sciences
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.medecinesciences.org/10.1051/medsci/2002184429/pdf
Reference55 articles.
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3. Waxman DJ, Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression.Biochem J1992; 281 : 577–92.
4. Frueh FW, Zanger UM, Meyer UA. Extent and character of phenobarbital-mediated changes in gene expression in the liver.Mol Pharmacol1997; 51 : 363–9.
5. Whysner J, Ross PM, Williams GM. Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion.Pharmacol Ther1996; 71 : 153–91.
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