Abstract
A systematic search for non-conventional open reading frames in human DNA reveals a large number of small ORFs encoding peptides generally smaller than 100 amino-acids. These ORFs are transcribed and translated into small proteins, which are demonstrated to have functional significance by bulk CRISPR inactivation. Evidence is also found for bicistronic mRNAs including such a small ORF upstream of a canonical coding sequence. These findings add a new facet to our understanding of biological processes.
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
1 articles.
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1. Naissance d’un gène;médecine/sciences;2023-03