Abstract
Analysing the data recently presented by Jiankui He and assuming that it is authentic shows that the goal of abolishing the expression of CCR5 may have been reached for one of the resulting twins, although this remains to be proven. However, the canonical delta32 mutation has not been achieved. The various preliminary experiments and controls give some confidence that major off-target modifications have not occurred; again, this is difficult to exclude. Clearly, the requirements of perfect technical mastery of the process have not been met, to say nothing of the requirements for complete transparency and full societal approval.
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference10 articles.
1. Associated Press, le 26 novembre 2016 https://apnews.com/4997bb7aa36c45449b488e19ac83e86d.
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5. Liens vers le colloque de Hong Kong (l’accès au deuxième site, plus complet, est parfois aléatoire): http://www.nationalacademies.org/hk/ http://www.nationalacademies.org/gene-editing/2nd_summit/index.htm. Lien vers les diapositives de Jiankui He : https://drive.google.com/drive/folders/1T1zLTtHS2z_cgl29fN_7qJg7fLA4qlrd.
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