Abstract
This comprehensive manuscript explores the forefront of innovation in microneedle-based drug delivery systems, heralding a paradigm shift in the realm of transdermal medicine. It meticulously examines the landscape of available drug delivery systems, offering a deep dive into their fabrication techniques and providing an exhaustive classification of microneedles in all their diverse forms. Going beyond mere description, the study navigates the vast terrain of biomedical applications, shedding light on both the remarkable potential and the inherent limitations of microneedles. By critically examining the pitfalls and challenges in this field, the manuscript underscores the pivotal role of microneedles in revolutionizing the landscape of painless drug administration. The article culminates with a forward-looking perspective, discussing current applications and illuminating the transformative impact microneedle-based drug delivery systems are poised to make on healthcare practices. As transdermal drug delivery systems gain increasing attention for their unique advantages over conventional administration methods, this review serves as an indispensable resource summarizing the latest developments and emerging trends, catering to the research and business communities alike. It paves the way for a future where microneedles redefine how we administer medication, making it virtually painless and more precise.