Automation of intraoperative analysis of indicators the inflammatory response of neurosurgical patients undergoing brain tumors removal

Abstract

The data of the study of indicators of the inflammatory response, hormonal status, biochemical blood parameters in the perioperative period in neurosurgical patients undergoing surgery for tumors of the posterior cranial fossa are presented. This study included 65 patients. The surgery was performed under anesthesia with fentanyl (3-5 µg / kg-hour), clonidine (1-2 µg / kg-hour), and propofol (3-5 mg / kg-hour). A significant increase in the level of interleukin 10 was observed at the level of hemostasis. The day after surgery, the level of Interleukin 6 increased significantly. During hemostasis, there was a temporary increase in ACTH, cortisol, and prolactin levels. The day after the surgery, rates returned to their original levels. Under conditions of persistent neurovegetative, a sufficient humoral response to surgical trauma was noted.