Biodegradable Polymer Biomaterials for Tissue Engineering Applications: A Critical Review

Abstract

This critical review explores the application of biodegradable polymer biomaterials in tissue engineering, highlighting their potential to revolutionize regenerative medicine and tissue substitute. Biodegradable polymers, due to their ability to mimic the extracellular matrix, offer a sustainable alternative for the development of tissue scaffolds that degrade at a rate matching new tissue formation. This review systematically covers the evolution, types, and applications of those materials, addressing both natural and synthetic polymers. Special attention is given to the fabrication techniques, along with 3-d bioprinting and nano-fabrication, that allow the introduction of scaffolds tailored for unique tissue engineering packages. The evaluation discusses the contemporary demanding situations, together with the balance among mechanical properties and biodegradability, and the mixing of scaffolds with host tissues. furthermore, it delves into future directions, including the development of hybrid biomaterials and the incorporation of bioactive molecules to enhance tissue regeneration. The advancements in biodegradable polymer biomaterials constitute a massive step in the direction of the development of more effective and personalised processes to tissue engineering.