The Effect of Morphology on the Biodegradation Behavior of Porous Magnesium Bone Scaffold

Abstract

The purpose of this study is to analyze the influence of morphology on the degrading behavior of porous magnesium bone scaffold by using computer simulation. Based on the experimental work, the three bone scaffold prepared with 30%, 41%, and 55% of porosity, respectively. The bone scaffold made of pure magnesium that immersed in simulated body fluid (SBF) for 72 hours with constant flow rates of 0.025 ml/min. After degradation, each specimen was scanned by μCT with a resolution of 17 μm. In this study, three different morphology before and after degradation was performed by computer simulation using the FSI method. Each specimen before and after degradation were given different bone strain (1000-3500 μstrain) that create displacement variations on the bone scaffold. Before degradation, the outcomes showed that the variation of displacement affects fluid characteristic change and for the specimen C (55% of porosity) generates the highest permeability with the value of 8.78 × 10-10 m2. After degradation, specimen A (30% of porosity) has a higher average shear stress of 2.04 × 10-3 Pa, specimen C (55% of porosity) has degradation rate of 3.37 mg/cm2/d and the highest porosity of 75.81%.