The study of the phenolic substances of the aerial part of the plant “Kokamaron” (Scutellaria Leptosiphon Juz.)

Abstract

In the article, the extraction of secondary metabolites, i.e., flavonoids, of the Scutellaria leptosiphon Juz plant, belonging to the Scutellaria family growing in Uzbekistan, and their chemical structure was studied. The methods of extraction, fractionation, thin-layer chromatography, column chromatography, paper chromatography, and quality reaction methods were used during the research. Also, the structure of flavonoids was analyzed by physical methods - ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The aerial part of Scutellaria leptosiphon Juz collected from the mountains of the Sherobod district of Surkhandarya region (Uzbekistan) was studied for the first time and it was found that it contains baicalein, wogonin and baicalein-7-O-β-D-glucopyranoside. Based on the results of chemical reactions and UV, IR, 1N NMR spectrum data, the structure of 3 flavonoid substances isolated from the examined plant was determined to be Baicalein (5,6,7-trihydroxyflavone), Vogonin (5,7-dihydroxy-8-methoxyflavone) and Baicalein-7-O-β-D-glucopyronazide substances. The results and conclusions of the research conducted on the isolation and chemical structure of the secondary metabolites of the S. Leptosiphon plant belonging to the Scutellaria family growing in the flora of Uzbekistan were presented.