Dynamics of glutathione reductase activity in rat liver tissues during cryodestruction of the right atrium

Abstract

The metabolic processes of the human body are based on multiple redox reactions and oxidative stress occurs when homeostasis is imbalanced. Antioxidant system of the body is represented by such enzymes as catalase, glutathione reductase, superoxidismutase and glutathione peroxidase. Objective: to study the dynamics of glutathione reductase activity in rat liver tissues after cryodestruction of right atrial myocardium to initiate oxidative stress. Materials and methods: 420 male rats were used. The rats were divided into two groups - intact and experimental, 210 animals in each. To initiate oxidative stress, the experimental group rats underwent cryodestruction of the right atrium. The activity of glutathione reductase in the liver tissue was determined by accumulation of oxidized glutathione before the experiment, as well as on 1, 3, 5, 7 and 14 days of the experiment. Conclusions: oxidative stress arising after cryodestruction of the right atrium up to the 7th day of the experiment provokes a decrease in the glutathione reductase activity in the rat liver tissue, but the start of reparative processes helps to restore the disturbed redox equilibrium in the body and normalize the enzyme level.