Author:
Zhang Hexing,Feng Baicheng,Jin Yan
Abstract
All-trans retinoic acid (10) was synthesized by β-ionone (5) through knoevenagel condensation, reduction and hydrolysis reaction. Then, hydroxyl-pinacolone retinoate (11) was prepared by the esterification with 1-hydroxy- 3, 3-dimethylbutan-2-ketone. This route not only reduces the synthesis steps but also helps to increase the yield. The structure of the product was characterized by 1H NMR and 13C NMR.
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