Author:
Makeyev Oleg,Korotkov Arteom,Kostyukova Svetlana,Shuman Evgeny,Desyatova Mariya
Abstract
Therapy of liver failure is a common and insufficiently resolved problem. One of the options for its solution it is a liver transplantation. However, this method has a number of drawbacks, which include a limited number of donors and transplant rejection. The use of autologous hepatocytes would allow significant progress to solve the problem under discussion. The work considers a method that allowed obtaining autologous hepatocytes by transdifferentiation of multipotent mesenchymal stromal cells using genetic engineering methods.
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