Influence of motor activity and polymorphism I/D of ACE on the affinity of oxygen for hemoglobin

Abstract

The influence of rs4646994 polymorphism of the ACE gene on the affinity of oxygen for hemoglobin among young men with different levels of physical activity has been studied. 245 young men aged 20-22 years were included in the study. All young men were divided into three groups depending on their motor activity: low (LMA), average (AMA) and high (HMA). SatO2, pO2, pCO2, p50 and HbO2 were analyzed in capillary blood of all examined young men. It was found out that I/I genotype of the ACE gene is associated with a decrease in the affinity of oxygen for hemoglobin both in LMA (p=0.022) and in HMA (p=0.000096). The intensification of physical activity among I/D and D/D genotypes is accompanied by an increase in the level of hemoglobin oxygenation in blood, while the I/I genotype with part of HbO2 does not change depending on motor activity. These features can be explained by the shift of the oxygen dissociation curve to the left among young men with the *D allele genotype, with an increase in physical activity. On the contrary, the I/I genotype of the ACE gene have efficient oxygen extraction to tissues, regardless of the level of motor activity compared to the D/D genotype.