Abstract
With the development of modern public health endeavors, Alzheimer's disease (AD) has emerged as an undeniable factor among the aging population. Familial Alzheimer's disease (FAD) and sporadic Alzheimer's disease (SAD) constitute the two primary classifications of Alzheimer's pathology. Through a comparison of their genetic mechanisms, clinical characteristics, and pathological changes, the intention is to unveil the distinctions and similarities between these two types. Research suggests that despite the presence of similar clinical manifestations in both types of Alzheimer's disease, there are significant differences in their genetic backgrounds and pathological features. A comprehensive understanding of the divergences and commonalities between FAD and SAD contributes to a deeper comprehension of the etiological mechanisms and clinical management of AD.