Abstract
Pancreatic cancer has a low incidence but remains one of the deadliest cancers, and its complex microenvironment is easy to coordinate metabolic changes and allow tumor cells to properly escape immunity. This article focuses on the immune microenvironment of pancreatic cancer, the current common immunotherapy methods and the state of clinical immunotherapy for pancreatic cancer and its outlook in the future. This article not only reviews the microenvironmental mechanisms studied by scientists, but also goes into more detail about recent developments in immunotechnology that have expanded our knowledge of how complex pancreatic cancer is. It is hoped that through the review of this article, readers can have a more detailed understanding of pancreatic cancer, which will help improve the survival rate of this too low disease through mechanism studies and clinical trials in the future.