Research advances in the protective effect of sulforaphane against kidney injury and related mechanisms

Abstract

Kidney injury and related diseases have become quite common in recent years, and have attracted more attention. Sulforaphane, a kind of isothiocyanate, is widely distributed in cruciferous plants and it is a common antioxidant. Specifically, sulforaphane can reduce oxidative damage by preventing cells from freeradical damage, preventing cells from degeneration, and acting as an anti-inflammation, etc. This study summarized the investigations of the effects of sulforaphane on kidney injury. This study discussed the mechanisms of sulforaphane on immune, renal ischemia-reperfusion, diabetic nephropathy, age-related, and other factors-induced kidney injury models and discussed the potential and relative mechanisms of sulforaphane for kidney injury protection.