Abstract
Objectives: Alcohol dependence (AD) imposes a significant economic burden and frequently cooccurs with other mental disorders. This study aimed to determine the impact of comorbidity severity among high-need, high-cost (HNHC) alcohol-related frequent attendees. (ARFAs). Methods: In a cross-sectional study, 128 participants filled out questionnaires. Assessing patients with the TLFB, APQ, SF-12, and Adult Service Use Schedule. Results: a) Psychiatric comorbidities are common in patients with AD. b) Comorbidity severity significantly predicts alcohol-related problems (APQ), quality of life (QoL), and emergency department (ED) attendance and admission after controlling for the influence of age and gender. c) Daily alcohol intake significantly modifies the relationship between comorbidity severity and emergency department attendance. Conclusions: When treating patients with AD, evaluating and considering the severity of comorbidity is essential.