Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against ear mite (Otodectes cynotis) infestations in cats

Abstract

Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel, nematodicidal and cestodicidal compounds, in NexGard®Combo, a novel topical endectoparasiticide formulation for cats. The efficacy of this formulation was assessed againstOtodectes cynotisin two laboratory studies conducted in South Africa and in the USA with local isolates, and in one field trial conducted in Europe. In each study, cats were randomly allocated to a placebo-treated control group and a novel formulation-treated group. In the laboratory studies, cats were treated at the minimum recommended dose; in the field trial, cats were treated at label dose. All included cats were diagnosed positive forO. cynotisprior to treatment by otoscopy. The main variable of efficacy was a comparison of the number of liveO. cynotiscollected in both ear canals of all cats in the treated and control groups, one month after treatment. Efficacy of the novel topical formulation exceeded 97% in the three studies. These studies demonstrated the high effectiveness of NexGard®Combo in cats for the treatment ofO. cynotisinfestations. No health abnormalities were attributed to the treatment in any of the studies.