Formulation and Characterization of Topical Anti-acne Spot Gel Containing Herbal Extracts

Abstract

This research work aimed to prepare the topical anti-acne spot gel incorporating the crude polyherbal extract that is a traditional Thai herbal recipe, namely “Ya-Sa-Marn-Phlae”. The topical anti-acne spot gels were prepared by add the crude polyherbal extract in each microemulsion or self-microemulsifying system and subsequently mixed in the blank anti-acne spot gel. The pH, viscosity, stability, contamination test, and skin irritation test were evaluated. The topical anti-acne spot gel formulations had a yellowish in color that was visually checked by researcher and photographed by digital camera. They had a pH near to a human skin and good viscosity which ease to use and safe to contact to the skin. They had a good stability and no contamination of Staphylococcus aureus and Escherichia coli. The topical anti-acne spot gels exhibited no oedema formation, and very slight erythema formation. Thus, the topical anti-acne spot gels were safe to apply on the skin without irritation.