1. Kore University of Enna, Enna, 94100, Italy
2. Medical Oncology Units, La Maddalena Clinic for Cancer, Palermo, 90100, Italy
3. Medical Oncology Unit, Policlinico P. Giaccone, University of Palermo, Palermo, 90100, Italy
4. Medical Oncology Unit, Istituto Clinico Humanitas, Catania, 95100Italy
5. Department of Clinical & Experimental Medicine, University of Catania, Catania - Italy, & Center of Experimental Oncology & Hematology AOU, Policlinico ‘G. Rodolico – San Marco’, Catania, 95100, Italy