Effect of chronic obstructive pulmonary disease and smoking on the outcome of COVID-19

Author:

Pranata R.1,Soeroto A. Y.2,Huang I.3,Lim M. A.1,Santoso P.2,Permana H.4,Lukito A. A.5

Affiliation:

1. Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia

2. Division of Respirology and Critical Illness, Department of Internal Medicine

3. Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Faculty of Medicine

4. Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia

5. Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia

Abstract

OBJECTIVE: To investigate the association between chronic obstructive pulmonary disease (COPD) and smoking with outcome in patients with COVID-19.METHODS: A systematic literature search was performed using PubMed, EuropePMC, SCOPUS and the Cochrane Central Database. A composite of poor outcome, mortality, severe COVID-19, the need for treatment in an intensive care unit (ICU) and disease progression were the outcomes of interest.RESULTS: Data on 4603 patients were pooled from 21 studies. COPD was associated with an increased risk for composite poor outcome (OR 5.01, 95%CI 3.06–8.22; P < 0.001; I2 0%), mortality (OR 4.36, 95%CI 1.45–13.10; P = 0.009; I2 0%), severe COVID-19 (OR 4.62, 95%CI 2.49–8.56; P < 0.001; I2 0%), ICU care (OR 8.33, 95%CI 1.27–54.56; P = 0.03; I2 0%), and disease progression (OR 8.42, 95%CI 1.60–44.27; P = 0.01; I2 0%). Smoking was found to increase the risk of composite poor outcome (OR 1.52, 95%CI 1.16–2.00; P = 0.005; I2 12%), and subgroup analysis showed that smoking was significant for increased risk of severe COVID-19 (OR 1.65, 95%CI 1.17–2.34; P = 0.004; I2 11%). Current smokers were at higher risk of composite poor outcomes (OR 1.58, 95%CI 1.10–2.27; P = 0.01; I2 0%) than former/non-smokers.CONCLUSION: Our systematic review and meta-analysis revealed that COPD and smoking were associated with poor outcomes in patients with COVID-19.

Publisher

International Union Against Tuberculosis and Lung Disease

Subject

Infectious Diseases,Pulmonary and Respiratory Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3