Plasma pharmacokinetics of bedaquiline administered by nasogastric tube in an intensive care unit-Reference-Cited by-同舟云学术

Plasma pharmacokinetics of bedaquiline administered by nasogastric tube in an intensive care unit

Published:2020-01-01 Issue:1 Volume:24 Page:110-112
ISSN:1027-3719
Container-title:The International Journal of Tuberculosis and Lung Disease
language:en
Short-container-title:int j tuberc lung dis

Author:

Dang E.¹,Sayagh F.²,Lê M. P.³,Neuville M.⁴,Sinnah F.²,Timsit J-F.⁵,Peytavin G.³

Affiliation:

1. Laboratoire de Pharmacologie-Toxicologie

2. Service de Réanimation médicale et infectieuse, Hôpital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris, Paris

3. Laboratoire de Pharmacologie-Toxicologie, Unité Mixte de Recherche 1137 Infection anti-microbien modelisation evolution, Université Paris Diderot, Sorbonne Paris Cité, Institut national de la santé et de la recherche médicale, Paris

4. Service de Réanimation Polyvalente, Hôpital Foch, Suresnes, France

5. Service de Réanimation médicale et infectieuse, Hôpital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris, Paris, Unité Mixte de Recherche 1137 Infection anti-microbien modelisation evolution, Université Paris Diderot, Sorbonne Paris Cité, Institut national de la santé et de la recherche médicale, Paris

Abstract

We present the case of a 21-year-old man admitted to the intensive care unit with multi-organ failure due to multidrug-resistant tuberculosis (TB). TB treatment initially comprised moxifloxacin, ethambutol, linezolid and amikacin administered intravenously. Due to suspected moxifloxacin-induced liver injury, we stopped all fluoroquinolones and switched to bedaquiline (BDQ), which is only available in tablets for oral administration. Since our patient had to be fed through a nasogastric tube (NGT), BDQ was administered after being crushed and dissolved in water; drug pharmacokinetics were studied using repeated blood sampling. Therapeutic drug monitoring showed that BDQ was detectable in blood plasma with a trough concentration above the supposed efficacy threshold, suggesting that this molecule could be administered through NGT.

Publisher

International Union Against Tuberculosis and Lung Disease

Subject

Infectious Diseases,Pulmonary and Respiratory Medicine

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