Perspectives from the 2nd International Post-Tuberculosis Symposium: mobilising advocacy and research for improved outcomes

Author:

Allwood B.W.1,Nightingale R.2,Agbota G.3,Auld S.4,Bisson G.P.5,Byrne A.6,Dunn R.7,Evans D.8,Hoddinott G.9,Günther G.10,Islam Z.11,Johnston J.C.12,Kalyatanda G.13,Khosa C.14,Marais S.15,Makanda G.16,Mashedi O.M.17,Meghji J.18,Mitnick C.19,Mulder C.20,Nkereuwem E.21,Nkereuwem O.21,Ozoh O.B.22,Rachow A.23,Romanowski K.12,Seddon J.A.24,Schoeman I.16,Thienemann F.25,Walker N.F.26,Wademan D.T.27,Wallis R.28,van der Zalm M.M.27

Affiliation:

1. Division of Pulmonology, Department of Medicine, Faculty of Medicine, Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa;

2. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, Department of Respiratory Medicine, Liverpool University Hospitals NHS foundation Trust, Liverpool, UK;

3. University of Montpellier, Recherches Translationnelles sur le VIH et les Maladies Infectieuses (TransVIHMI), Institut de recherche pour le Developpement (IRD), Institut National de la Sante et de la Recherche Médicale (INSERM), Montpellier, France;, Institut de Recherche Cliniques du Benin (IRCB), Abomey-Calavi, Benin;

4. Departments of Medicine, Epidemiology, and Global Health, Emory University School of Medicine and Rollins School of Public Health, Atlanta, GA,

5. Departments of Medicine and Biostatistics, Epidemiology, and Informatics, Division of Infectious Diseases and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;

6. Thoracic Medicine Division of the Heart Lung Stream of St Vincent’s Hospital Sydney Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia;, Socios En Salud Sucursal, Lima, Peru;

7. Division of Orthopaedic Surgery, Groote Schuur Hospital, Cape Town,

8. Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg,

9. Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia;

10. Department of Pulmonary Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Switzerland;

11. Alliance for Public Health, Kyiv, Ukraine;

12. University of British Columbia, Vancouver, BC, Canada;

13. Division of Infectious Disease and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA;

14. Instituto Nacional de Saúde, Marracuene, Mozambique;

15. Division of Neurology, Department of Medicine, University of Cape Town & Neurology Research Group, Neuroscience Institute, University of Cape Town, Cape Town,

16. TB Proof, Cape Town, South Africa;

17. Kenya Medical Research Institute, Centre for Respiratory Diseases Research, Nairobi, Kenya;

18. National Heart & Lung Institute, Imperial College London, London, UK;

19. Program in Infectious Disease and Social Change, Harvard Medical School, Boston, MA, USA;

20. Division TB Elimination and Health System Innovations, KNCV Tuberculosis Foundation, The Hague, The Netherlands;, Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centres, Amsterdam, The Netherlands;

21. Vaccines and Immunity Theme, MRC (Medical Research Council) Unit The Gambia at The London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara, The Gambia;

22. Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria;

23. Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), Munich, Germany;, German Center for Infection Research (DZIF), Partner Site Munich, Germany;, Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany;

24. Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;, Department of Infectious Disease, Imperial College London, London, UK;

25. General Medicine & Global Health (GMGH), Department of Medicine & Cape Heart Institute, University of Cape Town, South Africa;, Department of Internal Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland;

26. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool,

27. Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;

28. Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA

Abstract

In 2020, it was estimated that there were 155 million survivors of TB alive, all at risk of possible post TB disability. The 2nd International Post-Tuberculosis Symposium (Stellenbosch, South Africa) was held to increase global awareness and empower TB-affected communities to play an active role in driving the agenda. We aimed to update knowledge on post-TB life and illness, identify research priorities, build research collaborations and highlight the need to embed lung health outcomes in clinical TB trials and programmatic TB care services. The symposium was a multidisciplinary meeting that included clinicians, researchers, TB survivors, funders and policy makers. Ten academic working groups set their own goals and covered the following thematic areas: 1) patient engagement and perspectives; 2) epidemiology and modelling; 3) pathogenesis of post-TB sequelae; 4) post-TB lung disease; 5) cardiovascular and pulmonary vascular complications; 6) neuromuscular & skeletal complications; 7) paediatric complications; 8) economic-social and psychological (ESP) consequences; 9) prevention, treatment and management; 10) advocacy, policy and stakeholder engagement. The working groups provided important updates for their respective fields, highlighted research priorities, and made progress towards the standardisation and alignment of post-TB outcomes and definitions.

Publisher

International Union Against Tuberculosis and Lung Disease

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