The use of rats to detect drug-resistant TB-Reference-Cited by-同舟云学术

The use of rats to detect drug-resistant TB

Published:2023-03-21 Issue:1 Volume:13 Page:1-3
ISSN:2220-8372
Container-title:Public Health Action
language:en
Short-container-title:public health action

Author:

Beyene N.¹,Sitotaw A. L.²,Telila E. G.²,Gebre H. A.²,Alemu N. B.²,Burny R.³,Cox C.⁴,Soka J.⁵,Tegegn B.⁶,Wassie L.⁷,Bobosha K.⁷,Agizew T.¹

Affiliation:

1. Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia, APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania, Department of Biology, University of Antwerp, Belgium

2. Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia

3. APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania, APOPO, Research Project, Eduardo Mondlane University, Maputo, Mozambique

4. APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania, Department of Biology, University of Antwerp, Belgium

5. APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania, APOPO, Research Project, Tanzanian Veterinary Research Institute, Dar es Salaam, Tanzania

6. Addis Ababa City Administration Health Bureau, Tuberculosis/HIV, Addis Ababa, Ethiopia

7. AHRI, Mycobacterium, Diseases Research Directorate, Addis Ababa, Ethiopia

Abstract

Although detection of drug-susceptible TB by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling-trained African giant pouched rats has been known for more than a decade, the detection of drug-resistant TB (DR-TB) using rats has never been explored before. We present what we believe to be the first report on rifampicin-resistant TB (RR-TB) detected using Xpert® MTB/RIF Ultra, comparably identified by rats sniffing sputum samples from presumptive TB patients: 88% of RR-TB detected using Ultra were identified by the rats. Further evaluation of the usefulness of rats for large-scale DR-TB contact triage testing is needed, especially in low- and middle-income countries, where resources are limited.

Publisher

International Union Against Tuberculosis and Lung Disease

Subject

Public Health, Environmental and Occupational Health,Health Policy

Reference3 articles.

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