Prevalence of methicillin-resistant Staphylococcus aureus in a tertiary hospital in Nepal

Author:

Pradhan P.1,Rajbhandari P.1,Nagaraja S. B.2,Shrestha P.3,Grigoryan R.4,Satyanarayana S.5,Davtyan H.4

Affiliation:

1. Department of Medical Microbiology and Immunology, Patan Academy of Health Sciences, Lalitpur, Nepal

2. Department of Community Medicine, ESIC Medical College and Post Graduate Institute of Medical Science and Research, Bangalore, India

3. World Health Organization Health Emergencies Programme, Kathmandu, Nepal

4. Tuberculosis Research and Prevention Center, Yerevan, Armenia

5. Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, France

Abstract

SETTING: Patan Hospital, Lalitpur, Nepal.OBJECTIVES: To describe 1) the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its antibiotic sensitivity pattern; 2) the demographic and clinical characteristics associated with MRSA infections; and 3) the treatment outcomes of in-patients with MRSA infection among patients with S. aureus infection between January 2018 and December 2020.DESIGN: This was a cross-sectional study using electronic and paper-based hospital records of patients with S. aureus infection.RESULTS: Of the 1,804 patients with S. aureus infection, 1,027 patients (57%, 95% CI 55–59) had MRSA. The MRSA were susceptible to vancomycin (100%), linezolid (96%), doxycycline (96%), chloramphenicol (86%) and cotrimoxazole (70%), and resistant to erythromycin (68%), clindamycin (56%), gentamycin (58%), ciprofloxacin (92%) and ofloxacin (91%). The prevalence of MRSA was higher in 2019, among out-patients, and in respiratory samples, and lower in blood samples. Of the 142 in-patients with MRSA, 93% had a successful clinical outcome (cured/improved).CONCLUSION: More than 50% of patients with S. aureus infection had MRSA that were resistant to commonly available antibiotics. This calls for strengthening surveil-lance and good infection control practices in this hospital.

Publisher

International Union Against Tuberculosis and Lung Disease

Subject

Public Health, Environmental and Occupational Health,Health Policy

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