Caregiver willingness to give TPT to children living with drug-resistant TB patients-Reference-Cited by-同舟云学术

Caregiver willingness to give TPT to children living with drug-resistant TB patients

Published:2022-10-01 Issue:10 Volume:26 Page:949-955
ISSN:1027-3719
Container-title:The International Journal of Tuberculosis and Lung Disease
language:en
Short-container-title:int j tuberc lung dis

Author:

Rouzier V.¹,Murrill M.²,Kim S.³,Naini L.⁴,Shenje J.⁵,Mitchell E.⁶,Raesi M.⁷,Lourens M.⁸,Mendoza A.⁹,Conradie F.¹⁰,Suryavanshi N.¹¹,Hughes M.¹²,Shah S.¹³,Churchyard G.¹⁴,Swindells S.¹⁵,Hesseling A.¹⁶,Gupta; A.¹

Affiliation:

1. GHESKIO Centers, Port-au-Prince, Haiti and Weill Cornell Medicine, Center for Global Health, Department of Medicine, New York, NY

2. Johns Hopkins Medical Institutions, Baltimore, MD

3. Frontier Science Foundation, Brookline, MA

4. Social and Scientific Systems, Inc., Silver Springs, MD, USA

5. South African Tuberculosis Vaccine Initiative (SATVI), Cape Town, South Africa

6. University of Cape Town Lung Institute, Mowbray, South Africa

7. Gaborone Clinical Research Site, Gaborone, Botswana

8. TASK Applied Science Clinical Research Site, Bellville, South Africa

9. Asociación Civil Impacta Salud y Educación – Barranco Clinical Research Site, Lima, Peru

10. Sizwe Tropical Disease Hospital, Johannesburg, South Africa

11. Byramjee Jeejeebhoy Government Medical College Clinical Trials Unit, Pune, India

12. Harvard T H Chan School of Public Health, Boston, MA

13. Emory University Rollins School of Public Health, Atlanta, GA, USA

14. School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Aurum Institute, Johannesburg, South Africa

15. University of Nebraska Medical Center, Omaha, NE, USA

16. Desmond Tutu TB Centre, Stellenbosch University, Tygerberg, South Africa

Abstract

BACKGROUND Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited.METHODS This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged <13 years.RESULTS Of 743 adult and adolescent HHCs, 299 reported caring for children aged <13 years of age. The median caregiver age was 35 years (IQR 27–48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3–11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2–23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6–12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6–12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1–14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0–112.8).CONCLUSIONS A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDR TPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.

Publisher

International Union Against Tuberculosis and Lung Disease

Subject

Infectious Diseases,Pulmonary and Respiratory Medicine

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