Why are people still dying of drug-susceptible TB in Paris in the 21<sup>st</sup> century?-Reference-Cited by-同舟云学术

Why are people still dying of drug-susceptible TB in Paris in the 21^st century?

Published:2022-02-01 Issue:2 Volume:26 Page:142-149
ISSN:1027-3719
Container-title:The International Journal of Tuberculosis and Lung Disease
language:en
Short-container-title:int j tuberc lung dis

Author:

Beaumont A-L.¹,Doumbia A.¹,Château N.²,Meynard J-L.¹,Pacanowski J.¹,Valin N.¹,Cadranel J.³,Lalande V.⁴,Verdet C.⁴,Lassel L.⁵,Pialoux G.⁵,Fain O.⁶,Morgand M.⁶,Lacombe K.⁷,Surgers L.⁷

Affiliation:

1. Service des Maladies Infectieuses et Tropicales, Hôpital Saint-Antoine, F-75012, Groupes hospitalo-universitaires (GHU), Assistance Publique – Hôpitaux de Paris (AP-HP), Sorbonne Université, Paris, France

2. Institut Pierre Louis d´Epidémiologie et de Santé Publique, UMR-S 1136, Institut national de la santé et de la recherche médicale, F-75012, Sorbonne Université, Paris, France

3. Service de Pneumologie, Hôpital Tenon, F-75020, GHU AP-HP, Sorbonne Université, Paris, France

4. Service de Bactériologie-Hygiène, Hôpital Saint-Antoine, F-75012, GHU AP-HP, Sorbonne Université, AP-HP, Paris, France

5. Service des Maladies Infectieuses et Tropicales, Hôpital Tenon, F-75020, GHU AP-HP, Sorbonne Université, Paris, France

6. Service de Médecine Interne, Hôpital Saint-Antoine, GHU AP-HP, Sorbonne Université, F-75012, Paris, France

7. Service des Maladies Infectieuses et Tropicales, Hôpital Saint-Antoine, F-75012, Groupes hospitalo-universitaires (GHU), Assistance Publique – Hôpitaux de Paris (AP-HP), Sorbonne Université, Paris, France, Institut Pierre Louis d´Epidémiologie et de Santé Publique, UMR-S 1136, Institut national de la santé et de la recherche médicale, F-75012, Sorbonne Université, Paris, France

Abstract

BACKGROUND: Although the burden of TB is lower in France than in low-income countries, patients continue to die from TB in Paris. Our goal was to describe TB-related deaths and to identify associated risk factors.METHODS: We conducted a retrospective cohort study in two hospitals in Paris between 2013 and 2018. All patients with drug-susceptible TB were included and followed until end of treatment. The primary outcome was death. We performed univariate and multivariate analysis using Cox proportional hazard model.RESULTS: Of the 523 patients included, 362 were men (median age 37 years), of whom 24 patients died (4.5%). The final survival model concluded that age (HR 1.1 for each additional year), not living in one´s own accommodation (HR 5.9), being born in France (HR 8.0), being alcoholic (HR 4.2), having a history of cancer (HR 7.1) or meningeal or miliary TB (HR 8.2) were associated with a higher risk of death.CONCLUSION: The rate of TB-associated death is unacceptably high for a curable disease. To note, patients born in France were much more at risk of death than immigrants. We believe raising awareness among healthcare professionals is a potentially easy and efficient lever for improving care.

Publisher

International Union Against Tuberculosis and Lung Disease

Subject

Infectious Diseases,Pulmonary and Respiratory Medicine

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