Diagnostic accuracy of the Xpert® MTB/RIF cycle threshold level to predict smear positivity: a meta-analysis

Author:

Lange B.1,Khan P.2,Kalmambetova G.3,Al-Darraji H. A.4,Alland D.5,Antonenka U.6,Brown T.7,Balcells M. E.8,Blakemore R.9,Denkinger C. M.10,Dheda K.7,Hoffmann H.6,Kadyrov A.3,Lemaitre N.11,Miller M. B.12,Nikolayevskyy V.13,Ntinginya E. N.14,Ozkutuk N.15,Palacios J. J.16,Popowitch E. B.12,Porcel J. M.17,Teo J.18,Theron G.18,Kranzer K.19

Affiliation:

1. Centre for Chronic Immunodeficiency, Division of Infectious Diseases, Department of Internal Medicine II, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany

2. London School of Hygiene & Tropical Medicine, London, UK

3. National TB Reference Laboratory, National Centre of Phthisiology, Bishkek, Kyrgyzstan

4. Centre of Excellence for Research in AIDS, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, Centre for International Health, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand

5. Division of Infectious Disease, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA

6. Synlab MVZ Gauting, Institute of Microbiology and Laboratory Medicine, World Health Organization Supranational Reference Laboratory of Tuberculosis, Gauting, Germany

7. Lung Infection and Immunity Unit, Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa

8. Department of Infectious Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

9. Centre for International Health, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand

10. Foundation for Innovative New Diagnostics, Geneva, Switzerland

11. Laboratoire de Bactériologie-Hygiène, Centre Hospitalier Universitaire, Université de Lille-Nord de France, Unité Mixte de Recherche 8204, F-59021, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France

12. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

13. Synlab MVZ Gauting, Institute of Microbiology and Laboratory Medicine, World Health Organization Supranational Reference Laboratory of Tuberculosis, Gauting, Germany, Department of Medicine, Imperial College London, UK

14. Mbeya Medical Research Centre, National Institute for Medical Research, Dar es Salaam, Tanzania

15. Celal Bayar University Faculty of Medicine, Department of Medical Microbiology, Manisa, Turkey

16. Regional Mycobacteria Reference Center, Hospital Universitario Central de Asturias, Oviedo

17. Pleural Medicine Unit, Department of Internal Medicine, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain

18. Microbiology Unit, Department of Laboratory Medicine, National University Hospital, Singapore

19. Department of Science & Technology/National Research Foundation of Excellence for Biomedical Tuberculosis Research, and South African Medical Research Council Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa, National Reference Laboratory for Mycobacteria, FZ Borstel, Germany

Publisher

International Union Against Tuberculosis and Lung Disease

Subject

Infectious Diseases,Pulmonary and Respiratory Medicine

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