Copper-Catalyzed-Multicomponent Reaction towards the Synthesis of γ-Hydroxybutyrolactams

Abstract

Copper-catalyzed-multicomponent reaction has been applied to prepare several examples γ-hydroxybutyrolactams. The synthesis of γ-hydroxybutyrolactams occurred via cascade sequence comprising Sonogashira coupling, heterocyclization and nucleophilic addition reactions. The reaction involved the starting materials of (Z)-3-iodobutenoic acid, terminal alkynes and butylamine. The results showed that electronic effect of terminal alkynes played important role in synthesis of γ-hydroxybutyrolactams. The multicomponent reaction allowed us to obtain the desired products and to create multiple bonds in one-pot fashion.