Affiliation:
1. Xi'an Shiyou University
2. Shaanxi Research Design Institute of Petroleum and Chemical Industry
Abstract
A simple approach for the synthesis of Ortho Phthaloyl Chloride(OPC) was studied .Response surface methodology (RSM) was used to optimize the synthesis conditions of OPC. A 4-factor central composite design (CCD) was used for experimental design and analysis to obtain the optimal processing parameters, such as amount of triphosgene(BTC), amount of catalyst, reaction temperature and time. The 3-D response surface and the contour plots derived from the mathematical models were applied to determine the optimal conditions. The optimum reaction conditions were as follows: amount of BTC 62 g, amount of cat. 3.3 g, reaction temperature 75°C, reaction time 5 h. Under these conditions, The yield of OPC was 96.61%. Comparison of predicted and experimental values revealed good correspondence, implying that empirical model could be used to adequately describe the relationship between the factors and response in OPC synthesis process.
Publisher
Trans Tech Publications, Ltd.
Reference9 articles.
1. L.P. Kyrides. Phthalyl Chloride, J. Am. Chem. Soc. 1 206-208, (1937).
2. Qiu Wei-Jun. The Synthesis of Phthalyl Chloride, Ningbo Chemical Indistry. 1 35, (1997).
3. Shieh CJ, Akoh CC, Koehler PE. Four-factor response surface optimization of the enzymatic modification of triolein to structured lipids, J Am Oil Chem Soc. 72 6-10, (1995).
4. Soo EL, Salleh AB, Basri M, Rahman RNZA, Kamaruddin K. Response surface methodological study on lipase-catalyzed synthesis of amino acid surfactants, Process Biochem 39 1511–1518, (2004).
5. Xiuqing Kang. Study on the Synthesis of Imidacloprid's Intermediate 2-Chlorl-5-Methyl-Pyridne, Scientific Dissertation of Beijing University of Chemical Technology(2004).
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献