Study on Synthesis of N-Methyldipeptide N-Ns-N(Me)-L-Ala-N(Me)-L-lle-O<i><sup>t</sup></i>Bu-Reference-Cited by-同舟云学术

Study on Synthesis of N-Methyldipeptide N-Ns-N(Me)-L-Ala-N(Me)-L-lle-O^tBu

Published:2013-01 Issue: Volume:634-638 Page:1108-1111
ISSN:1662-8985
Container-title:Advanced Materials Research
language:
Short-container-title:AMR

Author:

Wang Xiao Ji¹,Zhang Jian Ting¹,Liu Dong Wang²,Tang Lin Jun¹,Li Yang¹

Affiliation:

1. Jiangxi Science and Technology Normal University

2. Jiangxi sicence and technology normal university

Abstract

The hindered N-methyldipeptide (N-Ns-N(Me)-L-Ala-N(Me)-L-Ile-OtBu), a segment of the new cyclodepsipeptide Apratoxin A[1] , which exhibit cytotoxycity against human tumor cell lines, was synthesized from L-Alanine and L-iso-Leucine through ten steps in overall yield of 49.4%.

Publisher

Trans Tech Publications, Ltd.

Subject

General Engineering

Link

https://www.scientific.net/AMR.634-638.1108.pdf

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