Affiliation:
1. Riga Technical University
Abstract
The high surface area per unit volume and core-shell configuration of electrospun nanofiber mat has a potential for drug delivery applications. Co-axial electrospinning technique resolves the limitation in the traditional transdermal drug delivery materials allowing to load a larger concentration of therapeutic agents per unit mass of the polymer. Encapsulating the drug in the fiber core provides protection and prolonged drug release. In the present study mats of core-shell PVA/PVP-FeOOH nanofibers were successfully formed by the coaxial electrospinning process for the first time. The visible light responsive FeOOH drug carrier material was incorporated in fiber core to provide non-invasive drug release on demand. The prepared materials posses visible light triggered release of organic methylene blue molecules.
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Reference7 articles.
1. L. Persano, A. Camposeo, C. Tekmen, D. Pisignano, Industrial Upscaling of Electrospinning and Applications of Polymer Nanofibers: A Review, Macromol. Mater. Eng. 289 (2013) 504-520.
2. Y. Qiu, K. Park, Environment-sensitive hydrogels for drug delivery, Adv Drug Deliver Rev. 53 (3) (2001) 321-339, doi.org/10.1016/S0169-409X(01)00203-4.
3. A. Kumari, S.K. Yadav, S.C. Yadav, Biodegradable polymeric nanoparticles based drug delivery systems, Colloid Surface B. 75 (1) (2010) 1-18, doi.org/10.1016/j.colsurfb.2009.09.001.
4. H.T. Sasmazel, O. Ozkan, Advances in Electrospinning of Nanofibers and their Biomedical Applications, Current Tissue Engineering. 2 (2013) 91.
5. R.P. Shaikh, P. Kumar, Y.E. Choonara, L.C. du Toit, V. Pillay, Crosslinked electrospun PVA nanofibrous membranes: elucidation of their physicochemical, physicomechanical and molecular disposition, Biofabrication. 4 (2012) 025002.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献