Optimization of Preparing Technology of Magnetic Carboxymethylchitosan Microspheres Molecular-Imprinted by 6-ethoxydihydrosanguinarine Using Response Surface Methodology

Abstract

In the present study, the response surface methodology (RSM) based on central composite design (CCD) was employed to optimize the preparation process of magnetic carboxymethylchitosan microspheres molecular-imprinted by 6-ethoxydihydrosanguinarine. The optimum parameters were as follows: CMCS concentration,3.24% ;CMCS/EtOSA ratio, 37.79 (g/g) and oil/water ratio, 2.76 (v/v).The adsorption rate from the optimized model was 39.34 (mg/g). Under the optimized conditions, the adsorption rate for the verifying experiments was well matches with the predicted value.