A Synthetic Approach for the Preparation of P1-AZT-5′-P3-d4T-5′-Triphosphate

Abstract

A novel and efficient method for the preparation of P1-AZT-5′-P3-d4T-5′-triphosphate has been developed. The title compound was characterized with 1H, 13C, and 31P NMR and mass spectrometry. The experimental results indicated that the employment of 4,5-dicyanoimidazole (DCI) as the activator could notably promote the coupling reaction of AZT 5′-phosphoropiperidate and d4T 5′-diphosphate.