Circulating Matrix Metalloproteinases, Tissue Inhibitors, Natriuretic Peptides, and Rigidity of the Great Arteries in Patients with HFpEF in 12 Month after Myocardial Infarction

Abstract

The paper is focused on the evaluation of the serum levels of matrix metalloproteinases (MMP -2, MMP -3, MMP - 9), tissue inhibitors (TIMP -1 and TIMP -2), natriuretic peptides, pusle wave velocity in patients (pts) with heart failure with preserved ejection fraction (HFpEF) in 12 month after ST elevation myocardial infarction (STEMI). The study included 55 pts. The serum levels of MMP -2, MMP -3, MMP - 9, the precursor of matrix metalloproteinase -1 (proMMP -1), TIMP -1 and TIMP -2, high-sensitivity C-reactive protein (hsCRP) were determined by ELISA. BNP in whole blood was determined on panels Triage BNP test. The most pts had class II NYHA (49%), as was often II class angina (53%). Increases in levels of BNP were dependent on class of NYHA. The stiffness of the great arteries was associated with increasing in BNP and NT-proBNP. There were no changes in levels of proMMP-1, MMP 3, MMP-2, MMP-9. But the serum levels of TIMP-1, hsCRP were increased in pts with HFpEF after STEMI. A positive relationship between hsCRP and TIMP-1 was obtained. Moreover, we found decreasing in levels of MMP-3 in pts with increased rigidity without the risk of cardiovascular events.