Effect of Silver Nanoparticle – Glycyrrhizic Acid Complexes in Ameliorating Drug Induced Oxidative Stress

Abstract

The prospective of the use of the silver nanoparticle complexes of glycyrrhizic acid in combating drug induced oxidative stress was studied by using three different model systems; paracetamol induced acute hepatotoxicity, doxorubicin induced acute cardiotoxicity and cisplatin induced acute renal toxicity in Swiss albino mice. The animals were administered with silver nanoparticle complexes of glycyrrhizic acid prior to the induction of paracetamol/doxorubicin/cisplatin toxicity and various parameters such as serum marker enzymes, tissue antioxidants and hisopathological analyses were performed. The results on the serum marker enzymes, tissue antioxidants and hisopathological analyses established the ability the complexes to offer protection to various organ systems against the oxidative damage induced by the respective drug treatments.KeywordsSilver Nanoparticle, histopathology, paracetamol, doxorubicin, cisplatin