Immediate and late Clinical Outcomes in Patients with Head and Neck Cancer Treated at the Ural Neutron Center

Abstract

The paper presents the analysis of the results of combined photon-neutron therapy (CPNT) in patients with malignant tumors of head and neck (H&N) inChelyabinsk region clinical oncological dispensary. In the basic group of patients with tumors of a throat the survival rate without relapses (SRWR) was 65 %, that is 30 % higher than in control group - 35 %. The general survival rate (GSR) was accordingly - 76 % and 66 % (р <0.005). In the basic and control group of patients with tumors of salivary gland WR the general survival rate was accordingly - 40 % and 14 % (p> 0.05). At tumors of the pharynx three - year WR after course of CPNT was 18.3 % higher (р=0.002) than in group thet underwent photon therapy. GSR was accordingly 46 % and 20 %. At tumors of oral cavity the CPNT increases survival rate without relapses at 11.5% and GSR at 17 %, in comparison with photon therapy (р <0.005). WR at tumors of nasopharynxes after CPNT was 62 %, and in control group 60 %. (р=0.05). When the size of tumor was T1 the GSR in basic group was 81 %, T2 - GSR was 62 %, and T3 - GSR was 70 %; In the control group accordingly was 52 %, 56 %, 35 %. CPNT in the program of radical course of PT increases a median of full tumor resorptions up to 84.52 % in the basic group, in control accordingly – 46.7 %. CPNT increases SRWR and GSR. The most meaningful difference in results of treatment according to SRWR and GSR was observed in patients with the size of primary tumor T3. Increase of SRWR and GSR was in groups at patients with tumors of a throat, salivary gland, pharynx where average tumor depth was up to 3.7- 4.5 cm.