Abstract
Poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) has improved mechanical properties over the existing PHA and our results have shown that PHBHHx has better biocompatibility over polyhydroxybutyrate (PHB) and polylactic acid (PLA). Surface treatment with lipases dramatically changed the material surface properties and increased the biocompatibility of the PHBHHx. PHBHHx and its PHB blends had been used to make three dimensional structures
and it has been found that cartilage, osteoblast, and fibroblasts all showed strong growth on the PHBHHx scaffolds. The growth was much better compared with PLA. The molecular studies also showed that mRNA encoding cartilages were strongly expressed when cartilage cells were grown on the PHBHHx. As PHBHHx has strong mechanical properties, easily processible and biodegradable, this material can be used to develop a new class of tissue engineering materials.
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Reference14 articles.
1. Chen GQ, Wu Q, Zhao K, Yu HP and Chan A. Chinese J of Polymer Sci. 18 (2000), 389-396.
2. He JD, Cheung MK, Yu PHF and Chen GQ. J. Appl. Polym. Sci. 82 (2001), 90-98.
3. Chen GQ, G. Zhang, S. J. Park, S. Y. Lee. Appl Microbiol Biotechnol 57 (2001), 50-55.
4. Doi Y, Kitamura S and Abe H. Macromolecules, 28(1995), 4822-4828.
5. Lu XY, Wu Q and Chen GQ. FEMS Microbiol Lett 221 (2003) , 97-101.
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