Affiliation:
1. INEB - Instituto de Engenharia Biomédica
2. Universidade do Porto
3. Institute for Technological Research
4. Institute for Molecular and Cell Biology (IBMC)
Abstract
In this study, the addition of calcium phosphate powders to an alginate matrix was
evaluated as a strategy to modulate enzyme release-kinetics from alginate microspheres and, simultaneously, to improve cell adhesion to the polymer. Pre-adsorption of the enzyme to the ceramic powders resulted in a more adequate release pattern. The ratio of ceramic-to-polymer had a pronounced effect on osteoblast adhesion to microspheres. Cells were only able to spread on
microspheres with the highest percentage of ceramic (0.4 w/w using a 1.5% w/v alginate solution).
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献