PLA-HPC Fibrous Membranes for Temperature-Responsive Drug Release-Reference-Cited by-同舟云学术

PLA-HPC Fibrous Membranes for Temperature-Responsive Drug Release

Published:2017-11 Issue: Volume:18 Page:34-41
ISSN:2297-3400
Container-title:Nano Hybrids and Composites
language:
Short-container-title:NHC

Author:

Kumar Manish¹,Wengerowsky Dagmar¹,Böttcher Florian¹,Sindelar Ralf²,Hytönen Vesa P.³,Renz Franz¹

Affiliation:

1. Leibniz Universität Hannover

2. University of Applied Science and Arts

3. University of Tampere

Abstract

In this study, Polylactic acid and Hydroxypropyl cellulose (PLA-HPC) fibers were fabricated by electrospinning. Methylene blue (MEB), as a model hydrophilic drug was embedded into PLA-HPC fibrous membranes. SEM results depicted that fibers are smooth, cylindrical, uniform and it confirmed the incorporation of MEB in PLA fibers alter the fibers morphology. Studies show the on-demand release of drug from PLA-HPC fibrous membranes under temperature stimuli which were absent in membranes manufactured out of PLA. This can be attributed to reversible volume phase transitions of HPC molecules in response to applied external temperature. This study may provide more efficient strategies for developing materials with on-demand drug release capability.

Publisher

Trans Tech Publications, Ltd.

Subject

General Chemical Engineering

Link

https://www.scientific.net/NHC.18.34.pdf

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