Affiliation:
1. Jiangxi Science and Technology Normal University
Abstract
A novel and efficient method for the preparation of α-D-mannose-1-phosphate has been developed. Phosphitylation of tetraacetylated D-mannose, hydrolysis yielded H-phosphonate monoester. Silylation of H-phosphonate, followed by oxidative coupling and hydrolysis gave protected D-mannose-1-phosphate. Finally, deprotection of tetraacetylated D-mannose-1-phosphate afforded D-mannose-1-phosphate in excellent yield.
Publisher
Trans Tech Publications, Ltd.