Affiliation:
1. Hebei Academy of Sciences
2. Hebei Fitness Bio-Technology Co.,Ltd
Abstract
A kind of enteric-coated pharmaceutical coating material, which can be dissolved in pH>5.5 medium, was successfully prepared by pre-emulsionsemi-continuous polymerization methods with equal molecular mass of methacrylic acid and ethyl acrylate as main raw materials. The effects of the initiator and chain transfer agent on the molecular weight and the performance of the emulsion were discussed. The obtained compound was used as the coating material of Lansoprazole capsule, and the dissolution rate was measured. The results show that polymethacrylat emulsion with 1.83×105 of molecular weight was obtained when the dosage of the initiator and the chain transfer agent is 0.43% and 0.79% of the total monomer mass, respectively. The dissolution rate of Lansoprazole capsule coated polymethacrylat emulsion in the pH 6.8 medium was greater than 75%.
Publisher
Trans Tech Publications, Ltd.
Reference6 articles.
1. D. Sauer, A. B. Watts and L.B. Coots: International Journal of Pharmaceutics. Vol. 367(2009), pp.20-28.
2. J. Breitkreutz: Journal of Controlled Release. Vol. 67(2000), pp.79-88.
3. J.Q. Hu, J.S. Yao and W.G. Zhu: Chemical New Materials. Vol. 5(2009), pp.31-37.
4. Y.P. Liu, Y.S. Wu: Chemistry World. Vol. 3(2004), pp.144-147.
5. C. Liu, H.F. Lei and Y.Y. Huo: Chemistry and Adhesion. Vol. 3(2012), p.33~36.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献