Synthesis of a New Chiral Selector Base on Pracoterol for Chiral Stationary Phase

Abstract

According to the chiral resolution mechanism and structures of Pirkle’s chiral stationary phase (CSP), a new amide chiral selector base on pracoterol has been prepared in this thesis. In order to get a better yield, all the conditions and purification conditions of the reactions were investigated, and the key products were characterized by HPLC, FT-IR and 1H NMR. This chiral selector may be developed as chiral selector of CSP.