Abstract
The synthesis of (S)-1-benzyl-3-pyrrolidinol is described. Starting from L-malic acid and benzylamine, we improved the synthesis of (S)-1-benzyl-3-hydroxypyrrolidine-2, 5-dione via melting reaction, without using any solvent. Followed by reduction with sodium borohydride-iodine in tetrahydrofuran, we synthesized the target compound. We used IR spectra to study the process of the reduction and modified the reaction conditions. It is the first time we reported (S)-1-benzyl-3-pyrrolidinol-borane which is the intermediate of the reduction with sodium borohydride-iodine system, and its spectral data (IR, 1H NMR, 11B NMR, MS spectroscopy).
Publisher
Trans Tech Publications, Ltd.
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