Determination of Metastable Zone Width, Induction, Period and Interfacial Energy of (R)-3-(methylamino)-1-Phenylpropanol Hydrochloride

Abstract

Solubility, metastable zone width and induction period of (R)-3-(methylamino)-1-phenylpropanol hydrochloride (MPH) in ethanol were determined by synthetic method at atmospheric pressure. The measured induction period data are also used to estimate the interfacial tension values of the system. The determined interfacial tension values have been also used to evaluate the nucleation parameters, such as the radius of the critical nuclei, the free energy change per unit volume, the critical free energy barriers.