Preparation of Bis-Functionalized 1,4-Diaminobutane Derivatives

Abstract

A three-component solvent-free method for the synthesis of a series of bis-α-aminophosphonate-modified butanes has been developed. The experimental results showed that the solvent-free reaction conditions without catalyst were optimal for the preparation of this type compounds. The synthesized title compounds were characterized by 1H, 13C, and 31P NMR and mass spectroscopy.