Affiliation:
1. Jiangxi Science and Technology Normal University
2. Jiangxi Provincial Colleges and Universities
Abstract
A series of d4T 5′-selenophosphoramidates were prepared in good yields from d4T 5′-H-phosphonamidates. H-Phosphonamidates were silylated with TMSCl, and then oxidized with selenium in the presence of DBU to afford d4T 5′-selenophosphoramidates. Due to the lowered electron density on the P atom of H-phosphonamidates, these intermediates were less prone to be oxidized than their P–O counterparts.
Publisher
Trans Tech Publications, Ltd.
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