Determination of Free Polyethylene Glycol in Cross-Linked Sodium Hyaluronate Gel

Author:

Zhao Yong Liang1,Meng Tian Tian1,Wang Wei Guo1,Wan Jia Li2

Affiliation:

1. Henan University of Technology

2. Henan Universe Intraocular Lens R&M Co.LTD

Abstract

Abstract: In this study we present a method for the determination of free polyethylene glycol in a gel. We detect the PEG residues of cross-linked sodium hyaluronate gel by spectrophotometry. The pretreatment of cross-linked sodium hyaluronate gel is special and the plot of working curve is unconventional. The precision, the recovery rate with marker, the reliability and repeatability of this method are tested and verified. The results indicated that the method has an excellent linear relationship in the range of 0-40.5µg mL-1. The regression equation is Y=0.0108X+0.2047 (R2=0.9994). The standard deviation of the detection method is 1.10% (n=9). The recovery rate with marker is 97.8% and the repeatability is perfect. In conclusion, the method possesses the properties of simple operation, quickness, excellent stability. Moreover this method can be applied for the quality control of gel products cross-linked by PEG and liquid samples containing PEG.

Publisher

Trans Tech Publications, Ltd.

Subject

General Engineering

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