A New Modeling Approach to Estimate the Concentration of Tibolone in Acetone Solvent through Raman Spectra

Abstract

Raman spectra are sensitive to solute, solid or polymorphs concentrations, particle size distribution and temperature. Characteristic peak positions of tibolone and acetone were observed at 1559cm-1 and 787cm-1. In this paper, we used the LabRAM HR800 System to detect the Raman spectra of 11 undersaturated standard solutions (concentration range 0-150 mg/ml) at 40°C; built model that estimating concentration of tibolone in acetone solvent by relating peak intensity ratio of the components to the concentration of the solution, and the mean estimated error was only 1.723% in the testing data. The results indicate that this method of estimating concentration is feasible and simple.