Mathematical Simulation and Experimental Investigation of Propranolol Hydrochloride Loading/releasing from Ion Exchange Fibers

Abstract

Ion-exchange fibers are promising drug delivery carriers,so it is important to predict the loading efficiency and loading capacity in the loading process and accurate prediction and control of the drug release profile(s) from the fibers for a given fiber-drug system under precise loading conditions. Impact of initial drug concentration, drug solution volume and fiber dose on the drug loading process and effect of loading drug concentration drug solution volume, fiber dose on the drug releasing process were assessed experimentally and theoretically. Two mathematical models based on Donnan theory and ion exchange equilibrium theory taking into account the chemical partition coefficient of D+, Na+and Cl-were developed to simulate the drug loading onto ion exchange fiber and releasing process respectively with the aim to gain mechanistic understanding on the factors affecting these two processes. Good correspondence between the experiment and theory has been established.