Hyaluronic Acid Production by Genetic Modified GRAS Strains

Author:

Fang Xiao1,Duan Rong Shuai1,Yang Hai Ying1,Liu Jing Feng1

Affiliation:

1. Shandong Institute of Commerce and Technology

Abstract

Hyaluronic acid is an important polysaccharide of various physiological functions. Nowadays, it is produced mainly through microbial fermentation of Streptococcus zooepidemicus. HA production in more safe and efficient genetic modified GRAS strains is a hot research area. Bacillus subtilis, Lactococcus lactis, Streptococcus thermophiles, Agrobacterium sp. , and some Escherichia coli strains, which were GRAS strains, had been selected for genetic engineering to express hyaluronic acid. Here, we provide a comprehensive review of HA production by these genetic modified GRAS strains.

Publisher

Trans Tech Publications, Ltd.

Subject

General Engineering

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